This mechanism might be in the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the clinical response to doxycycline need to be monitored intently. Phenytoin, sodium valproate, valproic acid: The impact of barbiturates on the metabolism of phenytoin seems to be variable. https://bradx099jwi3.frewwebs.com/profile