Cancer-causing HPV E6 oncoproteins are characterized by the presence of a PDZ binding motif (PBM) at their extreme carboxy terminus. It was long thought that this region of E6 had a sole function to confer interaction with a defined set of cellular substrates. However. more recent studies have shown that the E6 PBM has a complex pattern of regulation. https://www.bekindtopets.com/super-value-Keychron-M4-Wireless-4K-Mouse-flash-choice/