There's a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to lessen afferent soreness transmission and make analgesia. Therefore, drugs like clonidine that focus on alpha-2 receptors can influence the transmission of discomfort. For those who get dizzy when standing: https://www.proleviate.com/post/the-new-pain-killer-conolidine