Study into conolidine has led to discovery of the opioid receptor in the body known as ACKR3/CXCR7. ACKR3 is apparently the most sought after goal for conolidine, which also disregards another 4 classical opioid receptors(3). **This is the subjective assessment according to the power on the available informations and https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers